Towards Unifying Protein Evolution Theory
نویسنده
چکیده
There are many proposed models for protein domain evolution. The main contention [1], however, is between divergent [2] and convergent [3] models of evolution. Divergent evolution proposes that there was an ancestor to all domains that we see today and consequently all domains are historically related to each other. Convergent evolution claims that chance is largely responsible for the appearance of new kinds of domains. Convergent evolution explains the prevalence of certain types of structures by stating that those structures are more favorable and are often recycled for different functions. The distinction between convergent and divergent evolution is neither abstract nor purely academic. If divergent evolution is the primary model responsible for the appearance of new domains, then it is possible to reconstruct lineages of domains, follow structural change, and predict contextual functional ranges that occur due to well-defined evolutionary pressures. However, if convergent evolution is the main driving force behind the appearance of new structures and functions, in principle there should be no discernable structure–function relationship. An important step in understanding evolution is the quantification of dominant evolution scenario(s) as theoretical background for derivation of the structure–function correlation. Here, we describe recent advances in this direction.
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